Verena Scheper, DVM, PhD

Hannover Medical School

Research group leader

About

Verena Scheper, DVM, PhD, is leading the lab “Pharmacology of the Inner Ear” at the Department of Otorhinolaryngology (Head: Prof. Prof. Dr. med. Thomas Lenarz), Hannover Medical School, Hannover, Germany. Her research focus is on optimizing the hearing outcome of patients. The treatment strategies are pharmacologically based and focus either on hearing preservation before trauma insult will damage the hearing or on therapeutic approaches in already traumatized ears. Next to identification of appropriate drugs and relevant concentrations she develops and tests drug delivery strategies.
The delivery strategies range from established methods such as osmotic pump based local delivery (e.g. Dexamethasone, GDNF, BDNF, Artemin) to the development of nanoparticle based targeted delivery. In detail, lipidic nanocapsules, hyperbranched polylysines, micells, hydrogel and silica based particles were used to target inner ear cells and deliver growth factors or small molecules (BDNF, Rolipram, Dexamethasone). She tested stem cell, ARPE or fibroblast based drug delivery in animal models using encapsulating cell cages or ultra-high viscose alginate as matrix. Her methods range from primary culture for ear specific application to cell lines for MTT or free radical tests, from various animal models for hearing disabilities to management of clinical trials.
In recent studies she investigates the protective effect of proteins on noise induced hearing loss and the applicability of 3D-printing for drug loaded individualized round window and frontal sinus implants. Her research is funded by the European Commission (EU), the German Research Foundation (DFG), the Federal Ministry of Education and Research (BMBF) and industry.