Targeted and Stimuli-Responsive Biomaterials

Timeslot: Thursday, April 4, 2019 - 10:30am to 12:30pm
Track: Functional Biomaterials and Surfaces
Room: Skagit 3


Targeted and stimuli-responsive biomaterials, or “smart” drug delivery systems, can be used to effectively treat a variety of medical conditions. These materials have the potential to act rapidly and effectively, while avoiding various complications (e.g., off-site toxicity). Common stimuli used to trigger a change in these materials include pH, temperature, ionic strength, chemical and/or mechanical microenvironment, redox potential, and light. This session will focus on the development and application of these targeted and/or stimuli-responsive biomaterials including, but not limited to, cancer therapy and diagnostics, infection, cardiovascular disease, autoimmune diseases, etc.


  • 10:30:00 AM 213. Protease-triggered Delivery of an Anti-Inflammatory Drug for Modulation of Macrophage Proliferation, D. Nguyen*, B. Soeranaya, T. Truong, T. Dang; Nanyang Technological University, Singapore, Singapore

  • 10:45:00 AM 214. Targeted Delivery of Peptide-based Matrix Metalloproteinase?2 (MMP-2) Inhibitor in Dual Sensitive Nanoparticles with Platelet Membrane Camouflage for Ischemic Limb Treatment, Y. Dang*(1), N. Gao(1), H. Niu(2), Y. Guan(1), J. Guan(1); (1)Washington University in St. Louis, St. Louis, MO, USA, (2)The Ohio State University, Columbus, OH, USA

  • 11:00:00 AM 215. A Novel Matrix for Endometrium Regeneration by the Recruitment and Selective Capture of Endogenous Mesenchymal Stem Cells, L. Ma*, X. Zheng, X. Wang, L. Xin, C. Gao; Zhejiang University, Hangzhou, China

  • 11:15:00 AM 216. Magnetoliposome-Integrated Hydrogels for Delayed and Triggered Deliveries, S.Z. M. Madani*, A. Reisch, E. Hughes, G. Bothun, S. Kennedy; University of Rhode Island, Kingston, RI, USA

  • 11:30:00 AM 217. Photo-Crosslinking of Recombinant Protein Vesicles via Incorporation of Unnatural Amino Acids, Y. Li*; Georgia Institute of Technology, Atlanta, GA, USA

  • 11:45:00 AM 218. Magnetic Nanostructure-loaded Bicontinuous Nanospheres for Magnetic Resonance Imaging and Drug Delivery, M. Modak*, V. Nandwana, V. Dravid, E. Scott; Northwestern University, Evanston, IL, USA

  • 12:00:00 PM 219. 'Smart' Hydrogel for the Radiosensitization and Sustained Delivery of Therapeutics Triggered by X-Ray Irradiation, M. Bouche?*, J. Hsu, D. Cormode; University of Pennsylvania, Philadelphia, PA, USA

  • 12:15:00 PM 220. Biological Characterization of Intelligent Nanogels Synthesized by Inverse Emulsion Polymerization, J. Clegg*, J. Sun, E. Ander, A. Venkataraman, N. Peppas; The University of Texas at Austin, Austin, TX, USA