Recent Advances in Antimicrobial and Antibiofilm Materials 1
Timeslot: Thursday, April 4, 2019 - 1:45pm to 3:45pm
Track: Musculoskeletal and Craniofacial Biomaterials
Room: Skagit 2
Microbial infections are among the leading causes of death worldwide. Drug resistance and lack of new antimicrobial therapeutics increase the difficulty of treating these infections. Microbial biofilms can also severely complicate treatment and lead to chronic infections. These three-dimensional, surface attached microbial structures can form on a range of medical devices and biological surfaces and exhibit sophisticated defense mechanisms, evading traditional antimicrobial therapies. This session will focus on recent advances spanning industry and academia in developing materials for the treatment of bacterial, fungal, viral, biofilm and polymicrobial infections. Strategies discussed may range from synthesis of new antimicrobial molecules and macromolecules to fabrication of antimicrobial surfaces, device coatings, nano- and micro-particle drug carriers, hydrogels, etc.
Abstracts will be available for download on April 3, 2019.
1:45:00 PM 253. Invited Speaker: Vincent Rotello, PhD
2:15:00 PM 255. Dual Antibacterial Drug Loaded Nanoparticles Synergistically Improve Anti-Oral Biofilm Treatments, K. Sims, Jr.*(1), B. He(2), J. Maceren(2), Y. Liu(3), G. Hwang(3), H. Koo(3), D. Benoit(2); (1)University of Rochester School of Medicine and Dentistry, Rochester, NY, USA, (2)University of Rochester, Rochester, NY, USA, (3)University of Pennsylvania, Phi
2:30:00 PM 256. Optimization of PLGA Nanoparticles for Encapsulation of Enzyme for Elimination of Bacterial Biofilms, A. Doiron*(1), C. Han(2), J. Goodwine(2), K. Sauer(2); (1)University of Vermont, Burlington, VT, USA, (2)Binghamton University, Binghamton, NY, USA
2:45:00 PM 257. Codelivery of Lysostaphin and BMP-2 to Eliminate Acute Infections and Heal Critical-sized Segmental Bone Defects, P. Kalelkar*, C. Johnson, A. Garcia; Georgia Institute of Technology, Atlanta, GA, USA
3:00:00 PM 258. Delivery of Bupivacaine and Tolfenamic Acid from Ultra-High Molecular Weight Polyethylene: Multimodal Pain Relief and Synergistic Antibacterial Properties from Total Joint Implants, S. Grindy*(1,2), D. Gil(1,2), S. Hugard(1,2), O. Muratoglu(1,2), E. Oral(1,2); (1)Harvard Medical School, Boston, MA, USA, (2)Massachusetts General Hospital, Boston, MA, USA
3:15:00 PM 259. Investigating Antibiofilm Properties of IDR-1018 Peptide Loaded Hydrogels, S. Shukla*, A. Shukla; Brown University, Providence, RI, USA
3:30:00 PM 260. Biomimetic Phage Mimicking Antimicrobial Nanoparticles for Antibiotic Free, Bactericidal Action Against the ESKAPE Class of Pathogens, J. Hopf*, V. Kalwajtys, M. Waters, F. Fields, S. Lee, P. Nallathamby; University of Notre Dame, Notre Dame, IN, USA