Next-Generation Biomaterials for Treatment of Type 1 Diabetes

Timeslot: Thursday, April 4, 2019 - 1:45pm to 3:45pm
Track: Therapeutic Delivery
Room: Skagit 3

About

Type 1 diabetes is an autoimmune disease in which the insulin-producing beta cells of the pancreas are destroyed. This symposium will focus on translational biomaterials technologies for type 1 diabetes to improve survival, function, and/or delivery of insulin-producing cells or to improve diabetes monitoring and standards of care. Examples include: (i) materials delivering bioactive or immunomodulatory therapies, (ii) biomaterials addressing islet hypoxia, inflammation, and vascularization, (iii) biomaterial strategies for delivery of renewable sources of beta cells, and (iv) advancements in implantable glucose sensing technologies.

Abstracts

  • 1:45:00 PM 237. Invited Speaker: Ted Lee, PhD

  • 2:15:00 PM 239. Assembly of a Laminin-Nidogen Peri-Islet Matrix Improves Islet Function and Viability in PEG Hydrogels, J. Simonovich*(1), Y. Gonzalez-Vargas(1,2), N. Abuid(1), K. Ling(1), M. Becker(1), C. Stabler(1), E. Phelps(1); (1)University of Florida, Gainesville, FL, USA, (2)University of Puerto Rico-Mayagüez, Mayagüez, Puerto Rico

  • 2:30:00 PM 240. Engineering Transferrable Microvascular Meshes for a “Subcutaneous Pancreas”, M. Ma*; Cornell University, Ithaca, NY, USA

  • 2:45:00 PM 241. Phase-Changing Antioxidant Scaffold Shows Promise for Omentum Islet Transplantation: A Non-Human Primate Case Study, J. Burke*(1,2), Y. Zhu(1,2), X. Zhang(1,2), J. Post(3), D. Kaufman(3), X. Luo(2,4), G. Ameer(1,2,4); (1)McCormick School of Engineering, Northwestern University, Evanston, IL, USA, (2)Center for Advanced Regenerative Engineering, Northwestern University,

  • 3:00:00 PM 242. Methacrylic-Acid Based Polymer Coating of Polypropylene Mesh Device Improves Subcutaneous Islet Engraftment, V. Coindre*(1), S. Kinney(2), M. Sefton(1,2); (1)University of Toronto, Toronto, ON, Canada, (2)University of Toronto, Toronto, ON, Canada

  • 3:15:00 PM 243. Preventing Cell Death and Dysfunction for Human-sourced Beta Cells via Oxygen-generating Disk, J. Liang*, M. Coronel, C. Stabler; University of Florida, Gainesville, FL, USA

  • 3:30:00 PM 244. 3D-Printed Vascularizing Device for Immunoisolation of Islets, S. Parkhideh*(1), D. Sazer(1), G. Calderon(1), I. Kintslinger(1), Y. Wang(2), J. Oberholzer(2), J. Miller(1), O. Veiseh(1); (1)Rice University, Houston, TX, USA, (2)University of Virginia, Charlottesville, VA, USA

Invited Speaker(s)