Nanomaterials for Therapeutic Delivery
Timeslot: Wednesday, April 3, 2019 - 1:00pm to 3:00pm
Track: Therapeutic Delivery
Room: Skagit 3
Efficient delivery of therapeutics (including small or macromolecular drugs, biomolecules such as proteins or nucleotides, or engineered cells) is important to stimulate repair or regeneration of damaged or diseased tissues. Synthetic nanoengineered materials can be tailored for therapeutic delivery to cells and tissues for a range of biomedical applications. By modulating the physiochemical characteristics of nanomaterials, we can customize therapeutic efficacy, cellular internalization, biodistribution, and in vivo retention. This session will focus on emerging approaches to the design advanced nanomaterials for therapeutic delivery. These multidisciplinary approaches include modifications of synthetic and natural polymers with variety of chemistries, including click chemistry or supramolecular chemistries. Of special interest to this session are nanoscale engineered solutions for delivery of small and macro-molecule drugs, large therapeutic proteins and nucleotides for applications in regenerative medicine, stem cell engineering, immune modulation, antimicrobial, cardiovascular diseases and cancer therapeutics (in addition to the interactions of these nanoscale therapeutics in the body).
Abstracts will be available for download on April 3, 2019.
1:00:00 PM 5. DNA Caged-Micelle Erasable Labels for Multiplexed Immunohistochemistry, J. Winter*(1,2), E. Jergens(1), Y. Cui(2); (1)Ohio State University, Columbus, OH, USA, (2)The Ohio State University, Columbus, OH, USA
1:30:00 PM 7. Genetically Encoded Photocleavable Linkers for Protein Release from Biomaterials, J. Shadish*, A. Strange, C. DeForest; University of Washington, Seattle, WA, USA
1:45:00 PM 8. Using Click Chemistry to Target and Refill Drug-Eluting Depots, Y. Brudno*; University of North Carolina - Chapel Hill and North Carolina State University - Raleigh, Raleigh, NC, USA
2:00:00 PM 9. Designer Excipients Enable Oral Delivery of Poorly Soluble Drugs, J. Ting*(1), F. Bates(2), T. Reineke(2); (1)University of Chicago, Chicago, IL, USA, (2)University of Minnesota, Minneapolis, MN, USA
2:15:00 PM 10. IR820-Loaded PLGA Nanoparticles for Photothermal Therapy of Triple-Negative Breast Cancer, E. Day*, D. Valcourt, M. Dang; University of Delaware, Newark, DE, USA
2:30:00 PM 11. Effects of Nanometal Incorporation on Platelet-like Particle Properties and Antimicrobial Activity, E. Chee*(1), S. Nandi(1,2), E. Sproul(1,2), A. Brown(1,2); (1)Joint Department of Biomedical Engineering of University of North Carolina-Chapel Hill and North Carolina State University, Raleigh, NC, USA, (2)Comparative Medicine Institute, Raleigh, NC, USA
2:45:00 PM 12. The Role of Activation in Macrophage Phagocytosis and Exocytosis of Oligonucleotide Nanoformulations, E. Wayne*, C. Long, A. Kabanov; University of North Carolina-Chapel Hill, Chapel Hill, NC, USA