Nanomaterials / Drug Delivery Rapid Fire

Timeslot: Wednesday, April 3, 2019 - 3:15pm to 4:45pm
Track: Therapeutic Delivery
Room: Skagit 3

About

Efficient delivery of therapeutics (including small or macromolecular drugs, biomolecules such as proteins or nucleotides, or engineered cells) is important to stimulate repair or regeneration of damaged or diseased tissues. Synthetic nanoengineered materials can be tailored for therapeutic delivery to cells and tissues for a range of biomedical applications. By modulating the physiochemical characteristics of nanomaterials, we can customize therapeutic efficacy, cellular internalization, biodistribution, and in vivo retention. This session will focus on emerging approaches to the design advanced nanomaterials for therapeutic delivery. These multidisciplinary approaches include modifications of synthetic and natural polymers with variety of chemistries, including click chemistry or supramolecular chemistries. Of special interest to this session are nanoscale engineered solutions for delivery of small and macro-molecule drugs, large therapeutic proteins and nucleotides for applications in regenerative medicine, stem cell engineering, immune modulation, antimicrobial, cardiovascular diseases and cancer therapeutics (in addition to the interactions of these nanoscale therapeutics in the body).

Abstracts

  • 3:15:00 PM 72. Preparation of Injectable Thermogelling Nanoparticles for Chemokine Release and Cancer Cell Entrapment, M.K. Khang*, A. Hakamivala, J. Zhou, Y. Huang, L. Tang; University of Texas at Arlington, Arlington, TX, USA

  • 3:20:00 PM 73. Development of a Nanomaterial-based Localized Immunomodulatory and Anti-inflammatory (LISAI) Regimen to Improve Pancreatic Islets Transplantation, D. Velluto*, T. De Toni, A. Tomei; University of Miami, Miami, FL, USA

  • 3:25:00 PM 74. H2O2-activatable Nanoparticles for Contrast-enhanced Photoacoustic Imaging and Therapy of Thrombosed Vessels, D. Lee*, E. Jung, L. Jeong; Chonbuk National University, Jeonju, Republic of Korea

  • 3:30:00 PM 75. VCAM-1 Targeted Poly(?-Amino Ester) Nanoparticles for Gene Delivery Under Flow and to the Endothelium, N. DiStasio*(1,2), S. Lehoux(2), M. Tabrizian(1); (1)McGill University, Montreal, QC, Canada, (2)Lady Davis Institute for Medical Research, Montreal, QC, Canada

  • 3:35:00 PM 76. Injectable Dynamic Covalent Hydrogels of Boronic Acid Polymers Cross-Linked by Bioactive Plant-Derived Polyphenols, P. Delparastan*(1), Z. Huang(1), P. Burch(1), J. Cheng(1), Y. Cao(2), P. Messersmith(1); (1)University of California, Berkeley, Berkeley, CA, USA, (2)Nanjing University, Nanjing University, China

  • 3:45:00 PM 77. A Predictive Analytics Approach for Rational Design of Nanomedicines with Programmable Drug Release, A. Mullis*(1), S. Broderick(2), A. Binnebose(1), N. Peroutka-Bigus(1), B. Bellaire(1), K. Rajan(2), B. Narasimhan(1); (1)Iowa State University, Ames, IA, USA, (2)University at Buffalo, Buffalo, NY, USA

  • 3:50:00 PM 78. Cell Surface Vimentin as a Target for Liposome-based TRAIL Delivery to Metastatic Cancer Cells, M. Lopez Cavestany*, Z. Zhang, M. King; Vanderbilt University, Nashville, TN, USA

  • 3:55:00 PM 79. Supramolecular Galectin Assemblies Modulate T Cell Function, M. Fettis*(1), G. Hudalla(1); (1)University of Florida, Gainesville, FL, USA

  • 4:00:00 PM 80. High Throughput Identification of Synthetic Polymers with Globular and Protein-Like Features, R. Upadhya*, N.S. Murthy, S. Kosuri, M. Tamasi, A. Gormley; Rutgers University, Piscataway, NJ, USA

  • 4:05:00 PM 81. A Bilayer Swellable Drug-eluting Ureteric Stent: Localized Drug Delivery to Treat Urothelial Diseases, Y. Huang*(1), W.S. Lim(1), K. Chen(2), T.W. Chong(2), G. Xiong(1), S. Venkatraman(1); (1)Nanyang Technological University, Singapore, Singapore, (2)Singapore General Hospital, Singapore, Singapore

  • 4:15:00 PM 82. A Polymerization Friendly Dibenzoazacyclooctyne Monomer for Two-Step Bioconjugation, S. Kosuri*; Rutgers University, Piscataway, NJ, USA

  • 4:20:00 PM 83. Fabrication and Characterization of Silk Fibroin Microneedle Meshes for Perivascular Drug Delivery, J. Lee*(1), S.H. Park(1), E.H. Jang(2), J.-H. Kim(2), Y.-N. Youn(2), W. Ryu(1); (1)Yonsei University College of Engineering, Seoul, Republic of Korea, (2)Yonsei University College of Medicine, Seoul, Republic of Korea

  • 4:25:00 PM 84. Diffusion-Based Modeling and Drug Delivery of Gasotransmitters from Tissue Engineered Scaffolds, R. Jourdain*, S. Rottman, K. Washington, N. Abeyrathna, Y. Liao, C. Bashur; Florida Institute of Technology, Melbourne, FL, USA

  • 4:30:00 PM 85. Modular, Click Functionalized Hydrogels for Multilayered Tissue Engineering, J. Guo*(1), Y.S. Kim(1), V. Xie(1), J. Lam(2), P. Engel(3), A. Mikos(1); (1)Rice University, Houston, TX, USA, (2)Food and Drug Administration, Silver Spring, MD, USA, (3)William Marsh Rice University, Houston, TX, USA

  • 4:35:00 PM 86. Design of Reductively Responsive Amphiphilic Gel Capsules for Protein Delivery System, A. Kawamura*, H. Nakaura, T. Miyata; Kansai University, Suita, Japan