Immunomodulatory Biomaterials Rapid Fire

Timeslot: Wednesday, April 3, 2019 - 3:15pm to 4:45pm
Track: Immunomodulatory Biomaterials
Room: Yakima 1

About

Therapeutic modulation of the immune system is the emerging paradigm in medicine. For example, immunotherapy holds the promise of a cure for cancer, and is poised to expand into other therapeutic areas, such as inflammatory disorders, autoimmune diseases etc. However, several frontiers in immunotherapy remain to be explored. For example, can we design biomaterials for precise modulation/education of the immune system while avoiding toxicities? How can we locally active the immune response? Can we track the immune cells in real-time? The session will focus on engineered biomaterials for therapeutic immune modulation. Specifically, the session will cover topics ranging from biomaterials for delivery of immunomodulators and imaging agents, scaffolds, cell-based therapies etc. Several cutting edge immune engineering platforms will be included.

Abstracts

  • 3:15:00 PM 117. Immunomodulatory ECM-like Nanofibrous Microspheres for Accelerated Bone Regeneration in Diabetes Mellitus, X. Liu*, Z. Hu; Texas A&M University College of Dentistry, Dallas, TX, USA

  • 3:20:00 PM 118. Injectable Inflammation-Responsive Hydrogels Attenuate Symptoms of Load-Induced Osteoarthritis, T. Wheeler*(1), D. Holyoak(1), M. van der Meulen(1,2), A. Singh(1); (1)Cornell University, Ithaca, NY, USA, (2)Hospital for Special Surgery, New York, NY, USA

  • 3:25:00 PM 119. Single Dose, Combination Nanovaccine Provides Protection Against Influenza A Virus in Aged Animals, S. Senapati*, K. Ross, R. Darling, J. Alley, D. Verhoven, M. Wannemuehler, M. Kohut, S. Mallapragada, B. Narasimhan; Iowa State University, Ames, IA, USA

  • 3:30:00 PM 120. A Hydrogel Platform for Sustained Vaccine Exposure Enhances Humoral Immunity, G. Agmon*, E. Gale, E. Axpe, A. Yu, E. Appel; Stanford, Stanford, CA, USA

  • 3:35:00 PM 121. Pathogen-like Particles with Combination Adjuvants Induce Synergistic or Broadened Immune Responses, R. Toy*(1), P. Pradhan(1), M. Keenum(1), N. Jhita(2), E. Blanchard(1), N. Narang(1), M. Suthar(2), P. Santangelo(1), D. Shayakhmetov(2), K. Roy(1); (1)Georgia Institute of Technology, Atlanta, GA, USA, (2)Emory University, Atlanta, GA, USA

  • 3:45:00 PM 122. Attenuating Multiple Sclerosis in Mice with an Antigen-Specific Vaccine, A. Kwiatkowski*(1), J. Stewart(1), J. Cho(2), T. Drashansky(2), E. Helm(2), A. Zuniga(2), D. Avram(2), B. Keselowsky(1); (1)University of Florida, Gainesville, FL, USA, (2)University of Florida, Gainesville, FL, USA

  • 3:50:00 PM 123. An Antigen-specific Microparticle System Ameliorates Autoimmunity in Mouse Models of Type 1 Diabetes and Multiple Sclerosis, J. Stewart*(1), J. Lewis(2), A. Kwiatkowski(1), J. Cho(1), T. Drashansky(1), M. Clare-Salzler(1), C. Wasserfall(1), M. Atkinson(1), D. Avram(1), B. Keselowsky(1); (1)University of Florida, Gainesville, FL, USA, (2)University of California, Davis, Davis, C

  • 3:55:00 PM 124. Immunomodulation via Lentiviral Delivery from Microporous Scaffolds Alters Metastatic Tumor Cell Recruitment in vivo, G. Bushnell*(1), S. Rao(2), R. Hartfield(1), Y. Zhang(1), R. Oakes(1), J. Jeruss(1), L. Shea(1); (1)University of Michigan, Ann Arbor, MI, USA, (2)University of Alabama Tuscaloosa, Tuscaloosa, AL, USA

  • 4:00:00 PM 125. The Addition of the Amniotic Membrane to Mineralized Collagen Scaffolds for Immunomodulatory Bone Regeneration, M. Dewey*, E. Johnson, S. Slater, B. Harley; University of Illinois at Urbana-Champaign, Urbana, IL, USA

  • 4:05:00 PM 126. Near-Infrared-Irradiation-Induced Transformation of Surface Topography for Sequential Modulation of Macrophage Phenotypes to Match Tissue Healing Process, X. Zheng*, L. Xin, Y. Luo, H. Yang, L. Ma, C. Gao; Zhejiang University, Hangzhou, China

  • 4:15:00 PM 127. Modular Complement Assemblies as Defined Active Immunotherapies, K. Hainline*, M. Madhira, Z. Bernstein, Y. Wen, J. Collier; Duke University, Durham, NC, USA

  • 4:20:00 PM 128. Immunomodulatory Stem Cells to Alleviate the Foreign Body Response Against Implanted Biomaterials, R. Mohammadi*(1), G. Kim(1), R. Cao(1), s. Rodriguez(1), D. Tolsma(2), J. Lakey(1); (1)University of California, Irvine, CA, USA, (2)Northwestern University, Evanston, IL, USA

  • 4:25:00 PM 129. Controlled Release of M2-derived Macrophage Signals to Investigate Role in Foreign Body Response, C. Witherel*, K. Sao, B. Han, L. Han, R. Petrie, K. Spiller; Drexel University, Philadelphia, PA, USA

  • 4:30:00 PM 130. Immunotheranostic Nanomaterials for Monitoring Immunotherapy Response, A. Kulkarni*, A. Nguyen, A. Ramesh; University of Massachusetts, Amherst, MA, USA

  • 4:35:00 PM 131. Versatile Assembly of Polymeric Bicontinuous Nanospheres via Flash Nanoprecipitation, S. Bobbala*, S. Allen, N. Karabin, E. Scott; Northwestern University, Evanston, IL, USA