Functional Biomaterials to Control and Direct Cellular Function2

Timeslot: Saturday, April 6, 2019 - 10:15am to 12:15pm
Track: Functional Biomaterials and Surfaces
Room: Chelan 5

About

This session solicits abstracts that focus on the development functional biomaterials for tissue engineering applications. Specifically, studies that investigate biomaterial-directed cellular response in the absence of external factors (e.g., growth factors) will be highlighted. These studies include development of novel biomimetic approaches for the generation of tissue scaffolds with physicochemical properties (e.g., topography, composition, structure, mechanics) akin to the target tissue and assessment of the impact of these physicochemical cues on cell migration, proliferation, differentiation and de novo matrix production. Further, this session will also showcase in vivo studies that demonstrate the clinical translational capability of next generation functional biomaterials. Lastly, studies that focus on the investigation of biomaterial-based mechanisms that modulate cellular response are of interest.

Abstracts

  • 10:30:00 AM 485. Hyaluronic Acid-Based Hydrogels for Patient-Derived Xenograft Culture in a High Throughput Microfluidic Plate, D. Harrington*(1), L. Sablatura(2), K. Bircsak(3), P. Shepherd(4), N. Navone(4), P. Constantinou(4), A. Saleh(3); (1)The University of Texas Health Science Center, Houston, TX, USA, (2)Rice University, Houston, TX, USA, (3)MIMETAS, US, Gaithersburg, MD, U

  • 10:45:00 AM 486. Dissecting the Influences of Combinatorial Microenvironment on Hepatic Stellate Cell Behavior and Phenotype, I. Jain*(1), A. Brougham-Cook(1), D. Kukla(2), S. Khetani(2), G. Underhill(1); (1)University of Illinois at Urbana-Champaign, Urbana, IL, USA, (2)University of Illinois at Chicago, Chicago, IL, USA

  • 11:00:00 AM 487. High-throughput Mapping of Nanotopographies-Regulated Cell Behaviors by Large-scale Combinatorial Nanoarrays, L. Yang*, K.-B. Lee; Rutgers, the State University of New Jersey, Piscataway, NJ, USA

  • 11:15:00 AM 488. Microclot Array Elastometry for Integrated Measurement of Clot Biomechanics Under Fluid Shear, R. Zhao*, Z. Chen, J. Lu, C. Zhang, S. Neelamegham; State University of New York at Buffalo, Buffalo, NY, USA

  • 11:30:00 AM 489. Extracellular Matrix Enriched Spheroids for Enhanced Survival and Differentiation of Mesenchymal Stem Cells, T. Gonzalez-Fernandez*, A. Keown, A. Tenorio, K. Leach; University of California Davis, Davis, CA, USA

  • 11:45:00 AM 490. A Microfluidic Method for Creating Poly(ethylene glycol) Gradient Microgel Scaffolds to Modulate Human Mesenchymal Stem Cell Behavior, S. Xin*, J. Dai, A. Han, D. Alge; Texas A&M University, College Station, TX, USA

  • 12:00:00 PM 491. Photocrosslinked Bioglass Incorporated Methacrylated Collagen Hydrogels for Orthopedic Applications, N. Kajave*, T.-U. Nguyen, T. Schmitt, M. Fenn, V. Kishore; Florida Institute of Technology, Melbourne, FL, USA

  • 12:15:00 PM 492. Tendon Mimetic Magnetic Responsive Fibrous Scaffolds and Magneto-mechanical Stimulation Synergistically Promotes the Tenogenic Commitment of Human Adipose Derived Stem Cells, R. Domingues*(1,2,3), A. Tomás(1,2), A. Gonçalves(1,2), R. Reis(1,2,3), M. Gomes(1,2,3); (1)3B's Research Group, I3Bs – Research Institute on Biomaterials, Biodegradables and Biomimetics, Guimarães, Portugal, (2)ICVS/3B’s–PT Government Associate Laboratory, Braga/Guimarães, Portugal, (3)The Discoveries Centre for Regenerative and Precision Medicine, Guimarães, Portugal