Functional Biomaterials to Control and Direct Cellular Function 1
Timeslot: Friday, April 5, 2019 - 1:45pm to 3:45pm
Track: Functional Biomaterials and Surfaces
Room: Chelan 4
This session solicits abstracts that focus on the development functional biomaterials for tissue engineering applications. Specifically, studies that investigate biomaterial-directed cellular response in the absence of external factors (e.g., growth factors) will be highlighted. These studies include development of novel biomimetic approaches for the generation of tissue scaffolds with physicochemical properties (e.g., topography, composition, structure, mechanics) akin to the target tissue and assessment of the impact of these physicochemical cues on cell migration, proliferation, differentiation and de novo matrix production. Further, this session will also showcase in vivo studies that demonstrate the clinical translational capability of next generation functional biomaterials. Lastly, studies that focus on the investigation of biomaterial-based mechanisms that modulate cellular response are of interest.
Abstracts will be available for download on April 3, 2019.
1:45:00 PM 437. Invited Speaker: Akhilesh Gaharwar, PhD
2:15:00 PM 439. Soft Hydrogel as Cell Culture Substrate to Direct MSCs Proangiogenic Potential through ROS-NRF2-HIF Signaling, H. Yang*, C.Y. Tay, M.K.H. Lee; Nanyang Technological University, Singapore, Singapore
2:30:00 PM 440. Hydrogel Surfaces Promote MSC Expansion and Proregenerative Priming for Rotator Cuff Muscle Healing, M. Ogle*(1), G. Doron(1), M. Levy(1), J. Temenoff(1,2); (1)Georgia Institute of Technology and Emory University, Atlanta, GA, USA, (2)Georgia Institute of Technology, Atlanta, GA, USA
2:45:00 PM 441. Hydrogel-based in vitro Glioblastoma Spheroid Models, L. Hill*, M. Imaninezhad, J. Ortlund, J. Conley, S. Zustiak; Saint Louis University, Saint Louis, MO, USA
3:00:00 PM 442. Nascent Protein Secretion Directs Cell Mechanosensing and Function in Three-Dimensional Hydrogels, C. Claudia*(1,2), R. Mauck(1,2), J. Burdick(1); (1)University of Pennsylvania, Philadelphia, PA, USA, (2)VA Medical Center, Philadelphia, PA, USA
3:15:00 PM 443. Injectable Composite Hydrogels for Bone Repair in a Sheep Bone Defect Model, M. Gionet-Gonzales*(1), G. Ingavle(1), C. Vorwald(1), L. Bohannon(2), K. Clark(2), L. Galuppo(2), K. Leach(1,3); (1)University of California, Davis, Davis, CA, USA, (2)UC Davis School of Veterinary Medicine, Davis, CA, USA, (3)School of Medicine, UC Davis
3:30:00 PM 444. The Role of Substrate Stiffness in Stem Cell Transfection of Plasmid Dna Using Lipid-Based Nanocarriers, S. Modaresi*, S. Pacelli, J. Whitlow, A. Paul; University of Kansas, Lawrence, KS, USA