Engineering Reproduction

Timeslot: Thursday, April 4, 2019 - 4:15pm to 6:15pm
Track: Tissue Engineering and Regenerative Medicine
Room: Chelan 2


As a field, biomedical engineering continues to change the landscape of options available to individuals facing reproductive or endocrine failure for various reasons, such as genetic predisposition, age, iatrogenic effects of treatment, or disease. Engineered reproductive tissues that restore and support normal organ function are now emerging from work being done at the interface of reproductive biology, materials science, bioengineering, and advanced manufacturing. These engineered reproductive tissues and culture systems are enabling more physiologic in vitro modeling of homeostasis, development, disease, pregnancy, and aging. They are also being used for efficient screening of new pharmacologic agents for efficacy and reproductive toxicity. In this symposium, we will focus on recent work describing new engineering methods and applications in reproductive science and medicine, with a focus on biomaterials and microfluidic approaches that permit the generation of functional constructs at the “tissue/organ” level for use in both research and the clinic, with broader applications in other fields.


  • 4:15:00 PM 333. Invited Speaker

  • 4:30:00 PM 334. Invited Speaker

  • 4:45:00 PM 335. Rescuing the Primary: Lessons Learned from Inter-follicular Synergy, A. Jones*(1), H. Zhou(1), A. Shikanov(1,2); (1)University of Michigan, Ann Arbor, MI, USA, (2)The University of Michigan, Ann Arbor, MI, USA

  • 5:00:00 PM 336. Reconstructing the Ovarian Microenvironment: Culturing Follicles in an ECM-Sequestering PEG Matrix, C. Tomaszewski*(1), I. Kopyeva(2), A. Shikanov(1,3); (1)University of Michigan, Ann Arbor, MI, USA, (2)The University of Michigan, Ann Arbor, MI, USA, (3)U of Michigan, Ann Arbor, MI, USA

  • 5:15:00 PM 337. Bovine Ovary-derived Extracellular Matrix Hydrogel Supports in vitro Growth of Bovine Early Antral Follicles, E. Gargus*, H.C. Lee, J. Zhang, T. Woodruff; Northwestern University Feinberg School of Medicine, Chicago, IL, USA

  • 5:30:00 PM 338. Immunoisolating Poly(ethylene glycol)-Vinyl Sulfone Matrix Prevents Cancer Cells from Spreading Following Ovarian Tissue Autotransplantation, A. David*, J. Day, M. Hammersley, C. Long, A. Shikanov; University of Michigan, Ann Arbor, MI, USA

  • 5:45:00 PM 339. Dual Phased Poly(ethylene glycol) Immunoisolating Capsule Supports Ovarian Tissue Development and Precludes Sensitization of the Host Immune Response, J. Day*(1), A. David(1), M. Hammersley(1), M. Barbosa(2), M. Cascalho(2), A. Shikanov(1); (1)University of Michigan, Ann Arbor, MI, USA, (2)Michigan, Ann Arbor, MI, USA

  • 6:00:00 PM 340. Development of a Biomaterial Model of the Decidualized Endometrium, S. Zambuto*, B. Harley; University of Illinois at Urbana-Champaign, Urbana, IL, USA

Invited Speaker(s)