Engineered Microenvironments in Health and Disease Rapid Fire

Timeslot: Wednesday, April 3, 2019 - 3:15pm to 4:45pm
Track: Engineered Microenvironments
Room: Chelan 5


Biomaterials have been invaluable tools for understanding how cells respond to their microenvironment in both health and disease. Here, we invite contributions that develop biomaterial platforms for cell culture or tissue engineering. Session topics include the following: understanding of the mechanisms that determine cellular and immune responses to disease/injury/biomaterials, determining how biophysical and biochemical cues alter cellular behavior in 3D, identifying differences between 2D and 3D microenvironments in mediating cellular phenotype or response to treatment, developing complex tissue microstructures/organioids, culturing multiple types of cells within complex microenvironments, driving or enriching specific populations, developing improved approaches for utilization of patient derived or difficult to culture cells, drug screening within engineered microenvironments, and engineering microenvironments for therapeutic purposes.


  • 3:15:00 PM 132. Directing the Secretory Phenotype of Human Mesenchymal Stem Cells in Porous Assembled Microgel Networks, A. Caldwell*(1,2), V. Rao(1,2), K. Anseth(1,2); (1)University of Colorado Boulder, Boulder, CO, USA, (2)BioFrontiers Institute, Boulder, CO, USA

  • 3:20:00 PM 133. Micromolded Gelatin Hydrogels Crosslinked with Laminin for Disease on a Chip Applications, R. Besser*, R. Maciel, M. Dvornik, D. Carbonero, I. Claure, E. Jones, J. Reda, M. Saporta, A. Agarwal; University of Miami, Coral Gables, FL, USA

  • 3:25:00 PM 134. In vitro Model to Mimic Aggrecan Fragmentation Profiles After Spinal Cord Injury, M. McCrary*(1), Y.H. Song(1), S. Porvasnik(1), R. Wachs(1,2), A. Fosang(3,4), C. Schmidt(1); (1)University of Florida, Gainesville, FL, USA, (2)University of Nebraska- Lincoln, Lincoln, NE, USA, (3)University of Melbourne, Parkville, Australia, (4)Royal C

  • 3:30:00 PM 135. The Role of Osteopontin and Sex-Specific Differences in Valvular Interstitial Cells and Their Response to Biochemical Cues, M. Schroeder*(1,2), A. Gonzalez Rodriguez(1,2), K. Anseth(1,2); (1)University of Colorado Boulder, Boulder, CO, USA, (2)BioFrontiers Institute, Boulder, CO, USA

  • 3:35:00 PM 136. Using MicroRNA-122 Mimics or MicroRNA-451 Inhibitors to Prevent the Osteoarthritis Process, K. Scott*(1), M. Hays(1), D.J. Cohen(1), Z. Schwartz(1,2), B. Boyan(1,3); (1)Viriginia Commonwealth University, Richmond, VA, USA, (2)University of Texas Health Science Center at San Antonio, San Antonio, TX, USA, (3)Georgia Institute of Technology, Atlan

  • 3:45:00 PM 137. Mesenchymal Stem Cell Behaviors on 3D Geometric µ-Cavities, R. Subbiah*(1), M. Hunckler(1), A. García(1), R. Guldberg(1,2); (1)Georgia Institute of Technology, Atlanta, GA, USA, (2)University of Oregon, Eugene, OR, USA

  • 3:50:00 PM 138. Engineered Immune Neoplasms to Study BCR-TLR Cooperative Signaling, S. Shah*, K. Lee, C. York, A. Singh; Cornell University, Ithaca, NY, USA

  • 3:55:00 PM 139. Development of an Extracellular Matrix-Enriched Gelatin Sponge for Liver Wound Dressing, B. Wang*, W. Li; Alabama State University, Montgomery, AL, USA

  • 4:00:00 PM 140. Titanium with Nanotopography Induces Osteoblast Differentiation through Integrin ?3 Signaling Pathway, M. Beloti*(1), H. Lopes(1), G. Freitas(1), C. Elias(2), C. Tye(3), J. Stein(3), J. Lian(3), G. Stein(3), A. Rosa(1); (1)School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil, (2)Instituto Militar de Engenharia, Rio de Jane

  • 4:05:00 PM 141. In vitro Tridimensional Model of the Blood-Brain Barrier by Capillary Self-Organization, A. Figarol*(1), Y. Naka(1), M. Matsusaki(1,2); (1)Osaka University, Suita, Japan, (2)JST-PRESTO, Tokyo, Japan

  • 4:15:00 PM 142. Anthracene Based Dynamic Hydrogels to Probe Stiffness-Mediated Changes in Cardiac Fibroblasts, K. Günay*, T. Ceccato, J. Silver, K. Bannister, O. Bednarski, K. Anseth; Department of Chemical and Biological Engineering and The BioFrontiers Institute, University of Colorado at Boulder, Boulder, CO, USA

  • 4:20:00 PM 143. Characterizing and Modeling the Effects of Extracellular Matrix and Fibroblasts on Vascular Cell Function, E. Olszewski*(1), M. Kirby(1), M. Regier(1), R. Wang(1), K. Stevens(1,2), J. Davis(1,2); (1)University of Washington College of Engineering & School of Medicine, Seattle, WA, USA, (2)University of Washington School of Medicine, Seattle, WA, USA

  • 4:25:00 PM 144. Myofibril Remodeling of Human Stem Cell-Derived Cardiomyocytes Responding to Dynamic Surface Topography, Z. Ma*, S. Sun, S. Moore, C. Wang, A. Ash-Shakoor, J. Henderson; Syracuse University, Syracuse, NY, USA

  • 4:30:00 PM 145. Using Scaffolded Neuroblastoma to Model Cell-Driven Hypoxia, K. Ornell*, E. Newman, J. Coburn; Worcester Polytechnic Institute, Worcester, MA, USA

  • 4:35:00 PM 146. The Effect of MSC Phenotype on Osteogenesis and Vasculogenesis in Engineered Multiphase Microenvironments, N. Schott*, R. Annamalai, B. Juliar, J. Stegemann; The University of Michigan, Ann Arbor, MI, USA