Engineered Microenvironments in Health and Disease

Timeslot: Saturday, April 6, 2019 - 10:15am to 12:15pm
Track: Engineered Microenvironments
Room: Chelan 4

About

Biomaterials have been invaluable tools for understanding how cells respond to their microenvironment in both health and disease. Here, we invite contributions that develop biomaterial platforms for cell culture or tissue engineering. Session topics include the following: understanding of the mechanisms that determine cellular and immune responses to disease/injury/biomaterials, determining how biophysical and biochemical cues alter cellular behavior in 3D, identifying differences between 2D and 3D microenvironments in mediating cellular phenotype or response to treatment, developing complex tissue microstructures/organioids, culturing multiple types of cells within complex microenvironments, driving or enriching specific populations, developing improved approaches for utilization of patient derived or difficult to culture cells, drug screening within engineered microenvironments, and engineering microenvironments for therapeutic purposes.

Abstracts

  • 10:30:00 AM 501. 3D Engineered Patient-Derived Xenograft Tumors to Recapitulate the Obese Colorectal Cancer Tumor Microenvironment, I. Hassani*, B. Anbiah, B. Ahmed, N. Habbit, M. Greene, E. Lipke; Auburn University, Auburn, AL, USA

  • 10:45:00 AM 502. Pulmonary Fibrotic Microtissue Array for Screening Anti-fibrosis Therapy, R. Zhao*, M. Asmani; State University of New York at Buffalo, Buffalo, NY, USA

  • 11:00:00 AM 503. Engineered Hydrogels to Induce Breast Cancer Dormancy and Reactivation, J. Slater*, S. Pradhan; University of Delaware, Newark, DE, USA

  • 11:15:00 AM 504. Microfluidic Gradient Generator for Drug Testing on a Colorectal Tumor-on-a-Chip Disease Model, M. Carvalho*(1,2,3), D. Barata(4), L. Teixeira(4), S. Giselbrecht(4), R. Reis(1,2,3), M. Oliveira(1,2,3), P. Habibovi?(4), R. Truckenmüller(4); (1)I3B’s Research Institute on Biomaterials, Biodegradables and Biomimetics of University of Minho, Guimarães,

  • 11:30:00 AM 505. Cancer Associated Fibroblasts (CAFs) Confer Shear Resistance to Circulating Tumor Cells, A. Clinch*(1), N. Ortiz Otero(1,2), J. Marshall(2), M. King(1); (1)Vanderbilt University, Nashville, TN, USA, (2)Cornell University, Ithaca, NY, USA

  • 11:45:00 AM 506. Microfluidic Prostate Tumor-on-a-Chip Model for in vitro Recapitulation of the Tumor Microenvironment, N. Habbit*(1), B. Anbiah(1), L. Anderson(1), J. Suresh(1), I. Hassani(1), M. Eggert(2), S. Jasper(2), B. Prabhakarpandian(3), R. Arnold(2), E. Lipke(1); (1)Auburn University, Auburn University, AL, USA, (2)Auburn University Harrison School of Pharmacy, Au

  • 12:00:00 PM 507. Development of a 3D Hydrogel Model of Glioblastoma Invasion, L. Smith(1), L. Bahlmann*(1), L. Zhu(2), P. Dirks(3), M. Shoichet(1); (1)University of Toronto, Toronto, ON, Canada, (2)University of Calgary, Calgary, AB, Canada, (3)Hospital for Sick Children, Toronto, ON, Canada

  • 12:15:00 PM 508. Spatiotemporally Addressable Biomaterial Microenvironments for Modeling Pulmonary Fibrosis in vitro, C. Magin*(1,2), T. D'Ovidio(1), N. Darling(1); (1)University of Colorado, Anschutz Medical Campus, Aurora, CO, USA, (2)University of Colorado, Denver, Anschutz Medical Campus, Aurora, CO, USA