Engineered Biomaterials for Neural Applications 2

Timeslot: Saturday, April 6, 2019 - 10:15am to 12:15pm
Track: Sensory Biomaterials and Tissues
Room: Skagit 2

About

Researchers are constantly developing and applying new biomaterials to challenging problems of the peripheral and central nervous systems. Engineered biomaterials are uniquely positioned for use in creating, testing, and regenerating neural tissue for better in vitro models of injury and disease, therapeutic treatments, understanding neural development, and mapping the brain. This session will focus on cutting edge research in neural biomaterials including fundamental material development through pre-clinical studies. These include big questions surrounding diseases and injuries spanning neurons, astrocytes, oligodendrocytes, microglia, and Schwann cells. Presentations will be highly interdisciplinary at the interfaces of biology, chemistry, materials science, engineering, and neuroscience. Target applications of these materials include neural injury, neurodegenerative diseases, stroke, diagnostics, brain-machine interfaces, and brain cancer.

Abstracts

  • 10:30:00 AM 493. Probing Extracellular Matrix Structural Changes in Organotypic Rat Brain Slices Using Multiple Particle Tracking, M. McKenna*(1), H. Pontes(1), E. Nance(1,2,3,4); (1)University of Washington Department of Chemical Engineering, Seattle, WA, USA, (2)University of Washington Department of Molecular Engineering & Sciences Institute, Seattle, WA, USA, (3)University of Was

  • 10:45:00 AM 494. Hyaluronic Acid-Based Hydrogels as a 3D Culture Platform for Neural Stem/Progenitor Cells, S. Seidlits*, C. Walthers, J. Liang, R. Bierman, A. Sohrabi, J. Karam; University of California Los Angeles, Los Angeles, CA, USA

  • 11:00:00 AM 495. Ile-Lys-Val-Ala-Val and Leu-Arg-Glu Peptide Signaling in Combination with Matrix Metalloprotease Cleavable Crosslinkers Alter Extracellular Matrix Degrading Enzyme Expression and Axon Extension in Encapsulated Human Induced Pluripotent Stem Cell Derived n, L. Smith Callahan*, T.H. Perera; University of Texas Health Science Center at Houston, Houston, TX, USA

  • 11:15:00 AM 496. Redesigning SDF-1 Delivery Strategies with in vitro, in vivo, and in silico Analyses, K. Hickey*, S. Grassi, M. Caplan, S. Stabenfeldt; Arizona State University, Tempe, AZ, USA

  • 11:30:00 AM 497. SilkBridge: A Novel Biomimetic and Biocompatible Silk-based Nerve Conduit, G. Bassani*(1), M. Biagiotti(1), L. Muratori(2,3), V. Vincoli(1), G. Ronchi(2,3), A. Alessandrino(1), S. Geuna(2,3), G. Freddi(1); (1)Silk Biomaterials Srl, Lomazzo, Italy, (2)University of Torino, Orbassano, Italy, (3)Neuroscience Institute Cavalieri Ott

  • 11:45:00 AM 498. Delivery of Neurotrophic Factors in a Silk-based Nerve Conduit for Peripheral Nerve Repair, C. de Carvalho(1,2,3), W. Chang(4), R. Reis(1,2,3), J. Oliveira*(1,2,3), J. Kohn(4); (1)3Bs Research group, I3Bs – Research Institute on Biomaterials, Biodegradables and Biomimetics of University of Minho, Guimaraes, Portugal, (2)ICVS/3B’s–PT Government

  • 12:00:00 PM 499. Graphene-based Flexible Electronics Fabricated via Polymer Casting to Control Stem Cell Differentiation, M. Uz*, K. Jackson, M. Donta, J. Jung, D. Sakaguchi, J. Claussen, S. Mallapragada; Iowa State University, Ames, IA, USA

  • 12:15:00 PM 500. Fabrication of Nanofibrous Composite Meshes Incorporating Mg Metal particles for Nerve Repair Applications, N. Bhattarai*(1), U. Adhikari(1), X. An(2), S. Pixley(2), J. Sankar(1); (1)North Carolina A&T State University, Greensboro, NC, USA, (2)University of Cincinnati, Cincinnati, OH, USA