Bioengineering 3D Tissues for In Vitro Disease Modeling and Pulmonary Applications

Timeslot: Wednesday, April 3, 2019 - 1:00pm to 3:00pm
Track: Tissue Engineering and Regenerative Medicine
Room: Chelan 2

About

An understanding of the cellular and molecular mechanisms of human disease leading to the development of innovative therapies is a primary research goal. A barrier to understanding the disease microenvironment is the lack of a realistic tissue model for the long-term study of disease mechanisms. Two-dimensional culture systems are a widely used model for the studies on disease progression and preclinical drug assessments., however, they fail to reproduce the in-vivo disease microenvironment and the data produced are not always predictive. Advances in 3D printing and new biomaterial design may offer the potential to create in vitro tissue models that mimic the in vivo disease microenvironment. Such disease models can be used to investigate mechanisms of disease progression, for drug development and toxicology testing, and can eliminate the need for animal experimentation. The focus of this symposium will be on 3D printing technologies, biomaterial and bioink development and the opportunities and challenges leading to the development of models for cancer as well as orthopedic, vascular, and pulmonary diseases.

Abstracts

  • 1:00:00 PM 49. 3D Printing of Cell Spheroids Within Self-healing Hydrogels, A. Daly*, M. Davidson, K.H. Song, J. Burdick; University of Pennsylvania, Philadelphia, PA, USA

  • 1:15:00 PM 50. An Osteocyte 3D Culture System to Study Osteochondral Strains and Fluid Flow in an ex vivo Model, R. Wilmoth*, A. Aziz, A. Uzcategui, V. Ferguson, S. Bryant; University of Colorado Boulder, Boulder, CO, USA

  • 1:30:00 PM 51. Multiscale Modeling of Vascular Pathophysiology Using 3D Bioprinting, K. Gold*, A. Gaharwar, A. Jain, R. Dedas, T. Snell, N. Pandian; Texas A&M University, College Station, TX, USA

  • 1:45:00 PM 52. 3D Printing Unmodified Hydrogels Using Rail-Based Open Microfluidics, J. Day*(1), U. Lee(1), A. Haack(1), W. Lu(1), A. Theberge(1,2), E. Berthier(1,2,3,4); (1)University of Washington, Seattle, WA, USA, (2)Stacks to the Future, LLC, Madison, WI, USA, (3)Tasso, Inc., Seattle, WA, USA, (4)Salus Discovery, LLC, Madison, WI, US

  • 2:00:00 PM 53. Engineering an in vitro Model of Ductal Carcinoma In Situ Using FRESH 3D Bioprinting, J. Tashman*(1), T. Hinton(1), D. Brown(2), D. Shiwarski(1), A. Lee(1), A. Hudson(1), A. Lee(2), A. Feinberg(1); (1)Carnegie Mellon University, Pittsburgh, PA, USA, (2)University of Pittsburgh, Pittsburgh, PA, USA

  • 2:15:00 PM 54. Lung Extracellular Matrix Hydrogels for Mesenchymal Stem Cells 3D Bioprinting, J. Otero*(1,2), B. Falcones(1), E. Marhuenda(1,2,3), I. Almendros(1,2,4), D. Navajas(1,2,3), R. Farre(1,2,4); (1)Universitat de Barcelona, Barcelona, Spain, (2)CIBER for Respiratory Diseases, Madrid, Spain, (3)Institute for Bioengineering of Catalonia, Ba

  • 2:30:00 PM 55. The Role of ECM Composition in Bioengineered Lung Barrier Formation, R. Heise*(1), B. Young(1), K. Shankar(1), R. Pouliot(2), D. Weiss(2); (1)Virginia Commonwealth University, Richmond, VA, USA, (2)University of Vermont, Burlington, VT, USA

  • 2:45:00 PM 56. Bottom-up Strategies for Engineering Distal Lung Structure in vitro, N. Darling*(1), T. D'ovidio(1), C. Magin(1,2); (1)University of Colorado at Anschutz Medical Campus, Aurora, CO, USA, (2)University of Colorado at Denver, Aurora, CO, USA